Prevent virus transmission through donor blood transfusion

Diagnostic methods used by modern medicine for detection of viruses are not always accurate; sometimes the results of testing for the presence of viruses and determining their viability, for example, in donor blood, happen to be unreliable.

It is known that donor blood can be a virus carrier, but during the period of the serological window, his blood does not contain antigens and antibodies. Therefore the risk of transfusion of virus-infected donor blood, plasma and its components to the recipient can not be excluded.

donor bloodViruses posess lymphotropic properties, that is, the ability to penetrate and persist in the lymphocytes of a healthy person. Based on scientific and practical works and research carried out by New Medical Technologies, and with assistance of the scientists from the Institute of Epidemiology and Microbiology, modern innovative methods have been developed for detecting viruses and determining their viability, as well as a method for inactivating RNA and DNA containing viruses (COVID-19 is also RNA containing virus), including Hepatitis B, C and HIV viruses, influenza virus, hemorrhagic fever (Ebola group) possessing lymphotropic properties, and also inactivation method, that is, neutralization of bacteria, endospores and fungi.

Ovik Mkrtchyan, founder of New Medical Technologies, says, “While testing our research method at Center for Blood Transfusion, we found that 18% of samples taken with the use of traditional research methods that is, immunoenzyme method and polymerase chain reaction method, contained viral particles. The conclusion is that old methods are not effective enough, and the risk of transmission of dangerous diseases from donor to patient is real. We were the first who developed a correct algorithm for conducting research of donated blood; as a result we have created a new method for determining viable viruses possessing lymphotropism properties.”

New Medical Technologies company has developed and patented the following innovative methods: “Method for excluding false negative results when testing donated blood for infection with hepatitis viruses HBV and HCV, and HIV CC”, “Method for assessing the viability of lymphotropic viruses” and “Method for detecting lymphotropic viruses in biological matrix when the level of virus concentration is below the sensitivity threshold of the polymerase chain reaction method.” “Patents issued by the patent offices of the USA, Eurasia, Europe, Uzbekistan, ARIPO (African Patent Organization), as well as by patent organizations of countries such as China, Israel, the United Arab Emirates, South Africa, prove the recognition of our research developments as inventions, and that the technologies created by us are truly innovative and highly effective. These inventions are a breakthrough and a confident step in ensuring safety of the donorship system, including recipients’ safety. The method which we have developed for detecting and assessing the viability of lymphotropic viruses, has no analogues,” Ovik Mkrtchyan noted.

The advantage of these innovative methods is that there is no need to purchase new equipment in order to use them in practice; the equipment used in every diagnostic PCR laboratory is quite enough. The methods are simple, and assistants of PCR laboratories, after having read the instructions for conducting research and analyzing the results, can easily use the developed methods in practice without special long-time training and face-to-face consultations.

Another area of application of innovative methods developed by New Medical Technologies is the disinfection of medical instruments, other items and surfaces. Ovik Mkrtchyan said, “There is a certain number of medical instruments which can not be treated with the use of high temperatures and strong chemicals. Such instruments are used in dentistry, surgery, gynecology and cosmetology. As a result, there is a risk of infecting the patient with blood-borne infections, RNA and DNA containing viruses (it should be noted here that COVID-19 is an RNA containing virus), bacteria, spores and fungi.”

To solve this problem, New Medical Technologies company has created a special installation that applies a photodynamic disinfection method using methylene blue as a photosensitizer (sterilizing agent). The photodynamic method has been used for a long time in medicine for the treatment of diseases in dentistry, oncology, gynecology, urology, ophthalmology, diseases of the respiratory tract and throat, for the treatment of skin diseases, in cosmetology, as well as in the diagnosis of various diseases. Patents for this method have been issued by the USA, Eurasia and China.

The reliability and efficiency of the photodynamic method is too evident to require proof. The method is widely known and used in countries such as the USA, Germany, France, India, Russia and others.